Abstract:〔Abstract〕 Objective To evaluate the effects of both marginal fit and cementing with different luting agents on the microleakage of full-coverage crown systems. Methods Thirty-six extracted upper central incisors were prepared for fullcoverage crowns and were divided into three groups. Group 1: CAD/CAM-fabricated zro2, group 2: heat-pressed lithium-disilicate, and group 3: cast cr-co copings. Copings were made following standard techniques, and groups were assigned cementation with either self-adhesive resin cement (A) or glass-ionomer luting cement (B). The specimens were subjected to thermocycling, immersed in basic fuchsin solution, sectioned mesiodistally and buccolingually. The surface of each section was digitally photographed under a stereomicroscope. Microleakage was scored using a five-point scale, and the marginal gap was measured using image analysis software. Results The marginal discrepancy of each group was (82.7 ± 9.91)μm, (92.6 ± 9.53)μm and (96.5 ± 11.10)μm respectively. Group 1 showed signifi cantly smaller gaps than Group 2 and 3 (P < 0.05). Self-adhesive resin cement (A) showed a lower level of microleakage than glass-ionomer luting cement (B) in all groups (P < 0.05). Microleakage scores of '0' were 83 % for 1A, 50 % for 1B, 50 % for 2A, 16 % for 2B, 33 % for 3A and none for 3B. Conclusion Marginal discrepancy and cement type both had significant effects on microleakage. lower levels of microleakage were recorded with self-adhesive resin cement, while CAD/CAM-fabricated zro2 copings showed smaller marginal discrepancy and less microleakage in comparison to cast cr-co.