结直肠癌患者心率减速力与心率变异性变化及其相关性

Analysis on the Correlation Between Deceleration Capacity of Rate and Heart Rate Variability in Patients With Colorectal Cancer

摘要:

〔摘 要〕 目的：探讨结直肠癌患者的心率减速力（DC）与心率变异性（HRV）变化及其相关性。方法：选取 2019 年 1 月 至 2019 年 12 月厦门大学附属第一医院确诊结直肠癌的患者 143 例，在手术前或化疗、放疗前完成动态心电图检查，进行 DC 和 HRV 分析。结果：结直肠癌中晚期（Ⅲ、Ⅳ期）患者与早期（0、Ⅰ、Ⅱ期）患者相比，结直肠癌中晚期（Ⅲ、Ⅳ期） 患者与早期（0、Ⅰ、Ⅱ期）患者相比，RR 间期总体标准差（SDNN）、每 5 min 正常 RR 间期标准差的平均值（SDANN index）、DC 值明显降低，且 DC 值与 SDNN、SDANN index、相邻 RR 间期差值的均方根（rMSSD）、三角指数、极低频 功率（VLF）、低频功率（LF）、高频功率（HF）之间呈正相关。结论：结直肠癌患者完善动态心电图检查，能早发现其 自主神经功能病变，初步判断疾病病程，及时干预，改善预后。

关键词:结直肠癌;心率减速力;心率变异性

Abstract:

〔Abstract〕 Objective To investigate the correlation between deceleration capacity of rate(DC)and heart rate variability(HRV) in patients with colorectal cancer. Methods A total of 143 patients diagnosed with colorectal cancer in the Department of Colorectal Oncology of the First Affiliated Hospital of Xiamen University from January 2019 to December 2019 were selected. Ambulatory electrocardiography were performed before surgery, chemotherapy and radiotherapy and deceleration capacity of rate and heart rate variability were analyzed in patients. Result The results showed that SDNN, SDANN index and DC were significantly lower in stage III and IV colorectal cancer patients than those in stage 0, I and II, and there were positive correlation between DC and SDNN, SDANN index, RMSSD, trigonometric index, VLF, LF and HF. Conclusion The patients with colorectal cancer undergoing ambulatory electrocardiography examination can be a sensitive indicator in early diagnosis of autonomic system damage and judge the course of the canner, so as to give intervention treatment in time and improve the prognosis of patients.

Key words:Colorectal cancer; Deceleration capacity of rate; Heart rate variability