Abstract:〔Abstract〕 Objective To investigate and analyze the current status and influencing factors of professional decision– making self–efficacy of male nursing undergraduates. Methods Convenience sampling was used to select 323 male nursing undergraduates as the research objects. Using the career decision–making self–efficacy scale, they were investigated from the dimensions of self–evaluation, information collection, goal selection, planning and problem solving. Results The total score of professional decision–making self–efficacy of male nursing undergraduates is (89.00 ± 25.00), and the scores in each dimension are problem solving (3.60 ± 1.05), planning (3.58 ± 1.04), self–evaluation (3.55 ± 1.01), Target screening (3.54 ± 1.03), information collection (3.53 ± 1.04). The attitude towards the nursing profession and the education level of the mother are the influencing factors of the professional self–efficacy of male nursing undergraduates (P < 0.001). Conclusion Career decision–making self–efficacy has a good guiding role in the career selection, development and planning of male nursing undergraduates. For students with low career decision–making self–efficacy, higher nursing colleges can conduct targeted career prospect planning training in career decision–making. Schools, families and the society should help nursing undergraduates to establish a good support system in order to enhance their enthusiasm for the nursing profession and self–confidence in employment, thereby enhancing their career decision–making self–efficacy.