复发性流产患者蛋白 C、蛋白 S 活性 及抗凝血酶Ⅲ变化特征分析

Change Pattern of Plasma Protein C, Protein S and Antithrombin III in Patients with Recurrent Abortion

摘要:

〔摘 要〕 目的：探讨复发性流产患者血浆蛋白 C、蛋白 S 活性及抗凝血酶Ⅲ水平变化与妊娠结局的关系。方法：选取 2020 年 1 月至 2021 年 1 月福建省妇幼保健院收治的稽留流产无流产史的患者 50 例为稽留流产组，稽留流产且存在流产史 2 次及以上的患者 40 例为复发性流产组，同时选择接受首次人工流产术的患者 50 例为对照组。比较三组患者的血浆蛋白 C、 蛋白 S 活性与抗凝血酶Ⅲ水平。结果：复发性流产组患者血浆蛋白 C、蛋白 S 活性与抗凝血酶Ⅲ水平均低于对照组与稽留 流产组，差异具有统计学意义（P ＜ 0.05）；稽留流产组患者与对照组的血浆蛋白 C、蛋白 S 活性与抗凝血酶Ⅲ水平比较， 差异无统计学意义（P ＞ 0.05）。结论：复发性自然流产患者具有较高的血栓发生风险，血浆蛋白 C、蛋白 S 活性及抗凝 血酶Ⅲ水平可对血栓发生风险进行预测，针对性治疗可促使妊娠结局改善。

Abstract:

〔Abstract〕 Objective To investigate the relationship between plasma protein C, protein S activity, antithrombin III level and pregnancy outcome in patients with recurrent abortion. Methods 50 patients with missed abortion without abortion history treated in Fujian maternal and child health hospital from January 2020 to January 2021 were selected as the missed abortion group, 40 patients with missed abortion and abortion history twice or more were selected as the recurrent abortion group, and 50 patients who underwent induced abortion for the first time were selected as the control group. Plasma protein C, protein s activities and antithrombin III levels were compared among the three groups. Results The plasma protein C, protein s activities and antithrombin III levels in recurrent abortion group were significantly lower than those in control group and missed abortion group (P < 0.05); There was no significant difference in plasma protein C, protein S activity and antithrombin III level between missed abortion group and control group (P > 0.05). Conclusion Patients with recurrent spontaneous abortion have a high risk of thrombosis. Plasma protein C, protein S activity and antithrombin III level can predict the risk of thrombosis. Targeted treatment can improve pregnancy outcome.