乌司他丁在腹腔镜阑尾切除术中的应用

Application of Ulinastatin in Patients Undergoing Laparoscopic Appendectomy

摘要:

〔摘 要〕 目的：探讨乌司他丁在腹腔镜阑尾切除术中的应用。方法：选取 2020 年 3 月至 2021 年 3 月荥阳市人民医院 收治的 100 例接受阑尾切除术患者为研究对象，按照随机数字表法分为观察组（输注乌司他丁）与对照组（等量 0.9 % 氯 化钠注射液），各 50 例。比较两组患者炎症因子及应激指标水平。结果：两组患者术后 1 d、3 d 血清皮质醇（Cor）、 S100β、白细胞介素 –8（IL–8）、白细胞介素 –6（IL–6）、C 反应蛋白（CRP）水平均高于术前，差异具有统计学意义 （P ＜ 0.05）；观察组患者术后 Cor、S100β、IL–8、IL–6、CRP 水平均低于同期对照组，差异具有统计学意义（P ＜ 0.05）。 观察组患者术后 1 d、3 d 术后认知功能障碍（POCD）发生率均低于对照组，差异具有统计学意义（P ＜ 0.05）。结论： 乌司他丁可减轻腹腔镜阑尾切除患者炎症反应及应激反应，抑制 S100β 的表达，减少 POCD 等并发症的发生。

Abstract:

〔Abstract〕 Objective To explore the application of ulinastatin in patients undergoing laparoscopic appendectomy. Methods100 patients who underwent appendectomy in Xingyang people's Hospital from March 2020 to March 2021 were selected as the research objects. They were randomly divided into observation group (Ulinastatin infusion) and control group (equal amount of 0.9% sodium chloride injection), with 50 cases in each group. The levels of inflammatory factors and stress indexes were compared between the two groups. Results The levels of serum cortisol (Cor), S100β, interleukin-8 (IL-8), interleukin-6 (IL-6), and C-reactive protein (CRP) at 1 and 3 days after operation in the two groups All were higher than before operation, the difference was statistically significant (P < 0.05); The levels of Cor, S100β, IL-8, IL-6, and CRP in the observation group were lower than those in the control group at the same time, and the difference was statistically significant (P < 0.05). The incidence of postoperative cognitive dysfunction (POCD) in the observation group was lower than that in the control group at 1 and 3 days after operation, and the difference was statistically significant (P < 0.05). Conclusion Ulinastatin can reduce inflammatory reaction and stress reaction in patients with laparoscopic appendectomy and inhibit S100 β To reduce the occurrence of POCD and other complications.