Abstract:〔Abstract〕 Objective To explore the application effect of cranial ultrasound in the diagnosis of neonatal craniocerebral diseases. Methods The random sampling method selected 53 cases of neonatal craniocerebral diseases admitted to the Maternal and Child Health Family Planning Service Center of Yuancheng District, Heyuan City from May 2019 to May 2020 as the observation group, and 53 healthy newborns during the same period as the control group. Both groups underwent cranial ultrasound examination. Compare the implementation effects of the two groups. Results The detection rate of craniocerebral diseases in the observation group was higher than that of the control group, and the difference was statistically significant (P < 0.05). Conclusion The application of cranial ultrasound diagnosis in neonatal patients with brain injury can improve the diagnosis rate of patients with craniocerebral diseases.