艾司奥美拉唑治疗咽喉反流的疗效研究

Study on the Efficacy of Esmeprazole in the Treatment of Pharyngeal Reflux

摘要:

〔摘 要〕 目的：探讨艾司奥美拉唑治疗咽喉反流的疗效。方法：选取 2018 年 1 月至 2019 年 6 月在粤北人民医院耳鼻 喉科治疗的 80 例咽喉反流患者，随机分为两组，对照组和观察组各 40 例。均给予改善生活方式指导，在此基础上，对照 组口服奥美拉唑治疗，观察组口服艾司奥美拉唑治疗，比较两组患者的临床疗效、症状评分变化、不良反应。结果：观察 组患者治疗总有效率为 95.00 %，明显高于对照组的 75.00 %，差异具有统计学意义（P ＜ 0.05）。观察组患者治疗后咽喉 反流、声音嘶哑、慢性咳嗽、吞咽不畅等症状评分明显低于对照组，差异具有统计学意义（P ＜ 0.05）。观察组患者腹泻、 腹胀、恶心、头晕等不良反应发生率明显低于对照组，差异具有统计学意义（P ＜ 0.05）。结论：艾司奥美拉唑治疗咽喉 反流能有效缓解症状，减少胃酸反流，且不良反应发生率低。

Abstract:

〔Abstract〕Objective To investigate the efficacy of esmeprazole in the treatment of pharyngeal reflux. Methods 80 patients with pharyngeal reflux treated in the Department of Otolaryngology of North Guangdong People's Hospital from January 2018 to June 2019 were randomly divided into two groups, 40 cases in the control group and 40 cases in the observation group. On this basis, the control group was treated with oral omeprazole and the observation group was treated with oral Esmeprazole. The clinical efficacy, symptom score changes and adverse reactions of the two groups were compared. Results The total effective rate of the observation group was 95.00%, which was significantly higher than 75.00% of the control group (P < 0.05). After treatment, the symptom scores of pharyngeal reflux, hoarseness, chronic cough and poor swallowing in the observation group were significantly lower than those in the control group (P < 0.05). The incidence of adverse reactions such as diarrhea, abdominal distension, nausea and dizziness in the observation group was significantly lower than that in the control group (P < 0.05). Conclusion Ezmeprazole is effective in the treatment of pharyngeal reflux, it can effectively alleviate symptoms, reduce gastric acid reflux, and has a low incidence of adverse reactions, which has positive clinical significance.