坤泰胶囊联合来曲唑治疗多囊卵巢综合征不孕症的效果
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易秀娟,女,副主任医师,主要从事生殖内分泌科工作。

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R 711.75


Effect of Kuntai Capsule Combined with Letrozole in the Treatment of Infertility with Polycystic Ovary Syndrome
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    摘要:

    摘 要目的:探讨多囊卵巢综合征不孕症患者采用坤泰胶囊联合来曲唑治疗的临床效果。 方法:对重庆市万州区妇 幼保健院 2019 年 1 月至 2020 年 6 月期间收治的 60 例多囊卵巢综合征不孕症患者进行分组,以随机数字表法分成对照组与 观察组,各 30 例,观察组患者采用坤泰胶囊联合来曲唑治疗,对照组患者采用来曲唑治疗,比较两组患者治疗前后性激素 水平、卵巢卵泡质量、子宫内膜厚度、排卵率、妊娠率。 结果:治疗后,观察组患者的睾酮、雌二醇、促卵泡激素、促黄 体生成素水平均低于对照组,差异具有统计学意义(P < 0.05)。观察组患者的直径> 18 mm 成熟卵泡数多于对照组,子 宫内膜厚度大于对照组,差异具有统计学意义(P < 0.05)。治疗 50 d 后,观察组患者排卵率、妊娠率均高于对照组患者, 差异具有统计学意义(P < 0.05)。 结论:对多囊卵巢综合征不孕症患者采用坤泰胶囊联合来曲唑治疗的效果显著,可以 有效改善患者性激素水平及其卵巢卵泡质量,增加子宫内膜厚度,提高妊娠率。

    Abstract:

    AbstractObjective To investigate the clinical effect of Kuntai capsule combined with letrozole in the treatment of infertility with polycystic ovary syndrome. Methods 60 infertility patients with polycystic ovarian syndrome treated in Wanzhou district Maternal and Child Health Hospital of Chongqing from January 2019 to June 2020 were divided into control group and observation group by random number table, with 30 cases in each group. The patients in the observation group were treated with Kuntai capsule combined with letrozole, and the patients in the control group were treated with letrozole. The levels of sex hormones before and after treatment, ovarian follicle quality, endometrial thickness, ovulation rate and pregnancy rate were compared. Results After treatment, the levels of testosterone, estradiol, follicle stimulating hormone and luteinizing hormone in the observation group were significantly lower than those in the control group (P < 0.05). The number of mature follides with just over 18mm in diameter and endometrial thickness in the observation group were better than those in the control group (P < 0.05). After 50 days of treatment, the ovulation rate and pregnancy rate in the observation group were higher than those in the control group (P < 0.05). Conclusion Kuntai capsule combined with letrozole is effective in the treatment of infertility patients with polycystic ovary syndrome. It can effectively improve the level of sex hormone and the quality of ovarian follicles, increase the thickness of endometrium and improve the pregnancy rate.

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  • 收稿日期:2021-08-18
  • 在线发布日期: 2023-06-27
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