Abstract:〔Abstract〕 Objective To analyze the effects of neuroendoscopic minimally invasive surgery and conventional small bone window craniotomy hematoma removal on neurological function and postoperative quality of life in patients with hypertensive intracerebral hemorrhage, so as to obtain a better treatment plan. Methods 100 patients with hypertensive intracerebral hemorrhage from April 2020 to April 2021 were selected and divided into the observation group and the control group, with 50 cases in each group. The control group was treated with conventional small bone window craniotomy for hematoma removal, and the observation group was treated with neuroendoscopic minimally invasive surgery, and the curative effects of the two groups were compared. Results After treatment, the scores of the National Institutes of Health Stroke Scale (NIHSS) in the two groups decreased to varying degrees, while the activities of daily living scale (ADL), glasgow coma scale (GCS) and glasgow prognosis score (GOS) increased to varying degrees. The NIHSS score in the observation group was lower than that in the control group, and the ALD score, GCS score and GOS score in the observation group were higher than those in the control group, and the differences were statistically significant (P < 0.05). The operation time of the observation group was shorter than that of the control group, the amount of intraoperative blood loss of the observation group was less than that of the control group, the length of hospitalization of the observation group was shorter than that of the control group, and the hematoma clearance rate of the observation group was higher than that of the control group, all with statistical significances (P < 0.05). After 6 months of follow-up, there was 1 case (2.0 %) of rebleeding in the observation group, compared with 2 cases (4.0 %) in the control group, and there was no statistical significance (P > 0.05). After 6 months of follow-up, the incidence of complications in the observation group was 8.0%, lower than 32.0 % in the control group , and the difference was statistically significant (P < 0.05). Conclusion In the treatment of hypertensive intracerebral hemorrhage, neuroendoscopic minimally invasive surgery is more effective than conventional small bone window craniotomy hematoma removal in improving neurological function and postoperative quality of life.