Abstract:〔Abstract〕Objective To analyze and study the application effect of comprehensive functional nursing model in patients with ervical cancer after chemotherapy. Methods A total of 78 patients with cervical cancer admitted to Henan Provincial Cancer Hospital from September 2018 to October 2019 were selected and divided into intervention group (40 cases) and control group (38 cases) according to the implementation of comprehensive functional nursing mode. The effect of intervention was compared between the two groups. Results The objective remission rate in the intervention group was higher than that in the control group, and the difference was statistically significant (P < 0.05). The scores of short-term quality of life in the intervention group were higher than those in the control group, and the differences were statistically significant (P < 0.05). After the implementation of nursing, the self-rating anxiety scale (SAS) and self-rating depression scale (SDS) scores of patients in the two groups were reduced, and the scores of the intervention group were lower than those of the control group, the differences were statistically significant (P < 0.05). The incidence of nausea and vomiting, alopecia, bone marrow suppression, liver injury and drug dermatitis in the intervention group were significantly lower than those in the control group, the differences were statistically significant (P < 0.05). Conclusion Comprehensive functional nursing intervention for patients with postoperative chemotherapy of cervical cancer is beneficial to improve the overall therapeutic effect of patients.