Abstract:〔Abstract〕 Diabetic peripheral neuropathy (DPN) is one of the main causes of disability in diabetic patients. Traditional Chinese medicine has a significant effect, but lacks in-depth and systematic theoretical understanding. After years of clinical practice, the tutor SUN Xin-yu has his own rich experience in the treatment of DPN based on collateral theory. Tutor SUN Xin-yu believes that quench thirst for a long time, qi-yin deficiency, Phlegm, dampness, stasis and turbidity stagnate collaterals and collaterals injury, Yin and Yang are damaged over time, Yin and Yang deficiency, coupled with phlegm dampness and stasis, for a long time to brew into poison, limb collateral damage is even worse. Therefore, early attention to strengthening spleen qi, removing damp and turbidity, removing blood stasis and dredging collaterals. In the late stage, it is used to regulate Yin and Yang, resolve phlegm and turbidity, remove blood stasis and toxin, and dredge collaterals. Early diagnosis and early treatment should be followed in clinical treatment. The combination of traditional Chinese and western medicine treatment, sugar collaterals and treatment, internal and external treatment of the principle, syndrome differentiation and treatment of prescription medication, reduce the pain of patients, improve the quality of life of patients, reduce the rate of disability of diabetes patients.