Abstract:〔Abstract〕 Objective To investigate the clinical effect of internal heat acupuncture combined with extracorporeal shock wave on patients with thoracolumbar myofascitis. Methods A total of 76 patients with thoracolumback myofasciitis admitted to Quanzhou First Hospital Affiliated to Fujian Medical University from February 2020 to May 2021 were selected and divided into an observation group and a control group by computer random number table according to the medical sequence number, with 38 cases in each group. Both groups were treated with conventional analgesics, the control group was treated with extracorporeal shock wave, and the observation group was treated with internal heat acupuncture on the basis of the control group. The clinical efficacy of the two groups was compared. The traditional Chinese medicine symptom score, visual analogue scale (VAS) score, short form 36 health survey (SF-36) score, Oswestry disability index (ODI) score, and serum inflammatory cytokines levels before and after 2 weeks of treatment were compared. Results The total effective rate of the observation group was 92.11%, higher than 73.68% of the control group, and the difference was statistically significant (P < 0.05). After 2 weeks of treatment, the scores of tenderness, swelling, dysfunction and insomnia in the observation group were lower than those in the control group, with statistical significance (P < 0.05). After 2 weeks of treatment, the VAS and ODI scores of patients in the observation group were lower than those in the control group, while the SF-36 score was higher than that in the control group, with statistical significances (P < 0.05). After 2 weeks of treatment, the levels of serum interleukin-6 (IL-6) and C-reactive protein (CRP) in the observation group were lower than those in the control group, and the differences were statistically significant (P < 0.05). Conclusion Internal heat acupuncture has a significant effect on patients with thoracolumbar myofascitis, which can effectively promote the improvement of clinical symptoms, improve the quality of life and inhibit inflammatory factors.