营养状况对宫颈癌同步放化疗患者 临床结局、放化疗副反应的影响

Effects of Nutritional Status on Clinical Outcome and Side Effects of Concurrent Chemoradiotherapy for Cervical Cancer Patients

摘要:

〔摘 要〕 目的：探究营养状况对宫颈癌同步放化疗患者临床结局、放化疗副反应的影响。方法：选取 2018 年 3 月 至 2020 年 5 月于洛阳市第三人民医院接受同步放化疗的 60 例宫颈癌患者，根据营养状况分为正常营养组 32 例和异 常营养组 28 例。治疗 1 个周期后比较正常营养组与异常营养组的副反应发生率，再根据是否接受营养干预将异常营 养组分为干预组 15 例和无干预组 13 例，比较干预组与无干预组的副反应发生率、正常营养组与无干预组患者的 1 年 后临床结局。结果：正常营养组的骨髓抑制、肾功能损害、胃肠道反应的发生率均低于异常营养组，差异具有统计 学意义（P ＜ 0.05）；干预组的骨髓抑制、肾功能损害、胃肠道反应的发生率均低于无干预组，差异具有统计学意义 （P ＜ 0.05）；正常营养组的不良临床结局发生率为 3.23 %，明显低于异常营养无干预组的 23.08 %，差异具有统计 学意义（P ＜ 0.05）。结论：良好的营养状态可以减轻宫颈癌患者同步放化疗中的副反应，改善临床结局，且对营养 不良患者采取积极有效的营养干预可以减轻治疗副反应。

Abstract:

〔Abstract〕 Objective To explore the effects of nutritional status on clinical outcomes and side effects of concurrent chemoradiotherapy for cervical cancer patients. Methods A total of 60 patients with cervical cancer who received concurrent chemoradiotherapy in the Third People's Hospital of Luoyang from March 2018 to May 2020 were selected and divided into normal nutrition group with 32 cases and abnormal nutrition group with 28 cases according to their nutritional status. After 1 cycle of treatment, the incidence of adverse reactions between the normal nutrition group and the abnormal nutrition group was compared, and the abnormal nutrition group was divided into the intervention group with 15 cases and the non-intervention group with 13 cases according to whether nutritional intervention was accepted. The incidence of adverse reactions between the intervention group and the non-intervention group and the clinical outcomes of the normal nutrition group and the non-intervention group after 1 year were compared. Results The incidences of bone marrow suppression, renal impairment and gastrointestinal reactions in the normal nutrition group were lower than those in the abnormal nutrition group, and the differences were statistically significant (P < 0.05). The incidences of bone marrow suppression, renal impairment and gastrointestinal reactions in the intervention group were lower than those in the non-intervention group, with statistical significances (P < 0.05). The incidence of adverse clinical outcomes in the normal nutrition group was 3.23%, significantly lower than 23.08 % in the non-intervention group, the difference was statistically significant (P < 0.05). Conclusion The good nutritional status can reduce side effects of concurrent chemoradiotherapy in patients with cervical cancer and improve the clinical outcome, and positive and effective nutritional intervention in patients with malnutrition can reduce the side effects of treatment.