Abstract:〔Abstract〕 Objective To investigate the effect of ultrasound-guided stellate ganglion block (SGB) intervention on surgical outcomes, headache, nausea and vomiting in patients undergoing thyroid surgery. Methods 80 patients undergoing thyroid surgery in Nanping First Hospital from March 2021 to March 2022 were selected and divided into a control group and an observation group, with 40 cases in each group, according to random number table method. Both groups were received general anesthesia with endotracheal intubation. The control group received SGB intervention by blind detection before surgery, while the observation group was received SGB intervention under ultrasound guidance before surgery. The anaesthesia related indicators of the two groups were observed and compared. Results The effective time of anesthesia in the observation group was shorter than that in the control group, and the difference was statistically significant (P < 0.05). There was no significant difference in anesthesia maintenance time between the two groups (P > 0.05). The postoperative 24 h value-at-risk syetem (VAR) score of nausea and vomiting of the observation group was (0.12 ± 0.03) points, lower than (0.35 ± 0.08) points of the control group, and the difference was statistically significant (P < 0.05). Within 24 h, the incidence of vomiting in the observation group was 5.00 %, lower than 22.50 % in the control group, and the difference was statistically significant (P < 0.05). There was no significant difference in the incidence of headache at 6 h, 12 h, 24 h and 48 h between the two groups (P > 0.05). The total incidence of headache in the observation group was 12.50 %, lower than 32.50 % in the control group, and the difference was statistically significant (P < 0.05). The success rate of block in both groups was 100.00 %, and no complications were observed. Conclusion Preoperative application of ultrasound-guided SGB can effectively reduce the incidence of postoperative nausea and vomiting and reduce headache attacks.