中医针刺疗法治疗稳定期慢性阻塞性 肺疾病患者疗效的 Meta 分析

Meta Analysis of the Curative Effect of Acupuncture Therapy on Patients with Stable Chronic Obstructive Pulmonary Disease

摘要:

〔摘 要〕 目的：运用 Meta 分析方法评价中医针刺治疗慢性阻塞性肺疾病（COPD）稳定期的有效性。方法：通 过中文和英文数据库检索从 2018 年 1 月至 2021 年 10 月针刺治疗稳定期 COPD 的随机对照实验。随后利用 RevMan 5.4.1 软件对纳入文献进行文献风险评估、质量评价、系统评价及统计学分析。结果：共纳入 14 篇随机对照实验文献， 涉及 1173 名患者。Meta 结果显示，中医针刺疗法干预后，观察组用力肺活量（FVC）（MD ＝ 0.52，P = 0.0002）、 第 1 秒用力呼气容积占比（FEV1 %）（MD ＝ 3.40，P ＝ 0.003）、FEV1/FVC（MD ＝ 2.57，P ＝ 0.003）、最大呼 气流量（PEF）（SMD ＝ 0.82，P ＝ 0.003）、动脉血氧分压（PaO2）（MD ＝ 4.42，P ＝ 0.02）、6 min 步行试验（6MWT） （SMD ＝ 2.91，P ＝ 0.01）、慢性阻塞性肺疾病评分（CAT）（MD ＝ -1.67，P ＜ 0.00001）评分均优于对照组； 动脉二氧化碳分压（PaCO2）（MD ＝ -3.58，P ＜ 0.0001）低于对照组。结论：经分析中医针刺疗法治疗 COPD 稳 定期具有较好的疗效，有效的提高了患者的肺功能，改善生存质量。

Abstract:

〔Abstract〕 Objective To evaluate the efficacy of traditional Chinese medicine (TCM) acupuncture in the treatment of chronic obstructive pulmonary disease (COPD) in stable stage by Meta-analysis. Methods The Chinese and English databases were searched for randomized controlled trials of acupuncture in stable COPD from January 2018 to October 2021. Then, RevMan5.4.1 software was used to conduct literature risk assessment, quality evaluation, systematic review and statistical analysis on the included literature. Results A total of 14 randomized control experiment literature involving 1173 patients were included. Meta-results showed that after acupuncture intervention, forced vital capacity (FVC) (MD = 0.52, P = 0.0002), forced expiratory volume in one second (FEV1%) (MD = 3.4, P = 0.003), FEV1/FVC (MD = 2.57, P = 0.003), peak expiratory flow (PEF) (SMD = 0.82, P = 0.003), arterial partial pressure of oxygen (PaO2) (MD = 4.42, P = 0.02), six minutes walk test (6MWT) (SMD = 2.91, P = 0.01), chronic obstructive pulmonary disease score (CAT) (MD = -1.67，P < 0.00001) were better than those of the control group. Arterial partial pressure of carbon dioxide (PaCO2) (MD = -3.58，P < 0.0001) lower than that of the control group. Conclusion After analysis, acupuncture therapy of TCM has good curative effect in the treatment of stable COPD, which can effectively improve the lung function of patients and improve the quality of life.