Abstract:〔Abstract〕 Objective To investigate the clinical diagnostic value of ultrasonic gastroscopy with miniature probe for esophageal eminence lesions. Methods 44 patients with esophageal eminence lesions found by routine gastroscopy in endoscopy center's office of the Fourth People's Hospital of Chenzhou from March 2020 to April 2021were retrospectively selected as the research objects. Firstly, the lesions were scanned by ultrasonic gastroscopy with miniature probe, and the initial diagnosis was made by observing the ultrasound image characteristics of the lesions. According to the initial diagnosis, different endoscopic minimally invasive treatment schemes and pathological examination were used to compare the differences between pathological examination and micro-probe ultrasonic gastroscopy, to judge the accuracy of micro-probe ultrasonic gastroscopy in the diagnosis of esophageal eminence lesions, and to observe the safety of endoscopic treatment. Results The sensitivity, specificity and accuracy of micro-probe ultrasonic gastroscopy in the diagnosis of esophageal elevation lesions were 97.62 %, 50.00 % and 95.45 %, respectively. No gastrointestinal bleeding, perforation, infection and other complications occurred in 44 patients who received endoscopic minimally invasive treatment during and after operation, and the postoperative recovery was good. Conclusion The results of micro-probe ultrasonic gastroscopy for esophageal protrusion lesions are basically consistent with the pathological results. Under the guidance of micro-probe ultrasonic gastroscopy, there are no complications such as massive bleeding and perforation in patients with different endoscopic minimally invasive treatment schemes, which is safe.