Abstract: 〔Abstract〕 Objective To compare the clinical effects of different impression techniques in making fixed restoration impressions. Methods A total of 22 patients with fixed prosthesis and a total of 56 abutment teeth who were admitted to the Department of Stomatology of Shangqiu Central Hospital from October 2020 to December 2021 were selected as the research objects. According to the patient's admission order, different impression techniques were used to make fixed restoration impressions. Group A (finished tray plus alginate plus agar impression) had 18 abutment teeth; group B (finished tray plus silicone rubber impression material) had 20 abutments teeth; group C (finished tray plus single tooth tray plus silicone rubber impression) had 18 abutment teeth. Impressions were made on the patient's abutments, and the data obtained from the impressions were recorded, and the clinical effects of different impression techniques in making fixed restoration impressions were analyzed. Results In group A, 4 cases were excellent, 7 cases were good, 5 cases were qualified, and 2 cases were unqualified. In group B, 6 cases were excellent, 5 cases were good, 6 cases were qualified, and 3 cases were unqualified. In group C, 8 cases were excellent, 9 cases were good, 1 case was qualified, and 0 case was unqualified. The excellent rates of group B and group C were higher than that of group A, and the differences were statistically significant (P < 0.05), and no unqualified impression was found in group C; Kruskal-wallis rank sum test showed that there was no significant difference in the impression accuracy between group A and group B (P > 0.05), while there were significant differences between group C and group A and Group B (P < 0.05). Conclusion Compared with the other two impression techniques, the impression effect of the individual tooth tray plus silicone rubber impression technique is better, and it can clearly show the patient's prepared shoulder and the corresponding anatomical structure under the shoulder, which is helpful for the repair of the sulcus wing of the impression.