Abstract:〔Abstract〕 Objective To analyze and comparison the effect of laparoscopic and open surgery in the treatment of adult inguinal hernia. Methods A total of 103 adult patients with inguinal hernia admitted to Longyan Hospital of Traditional Chinese Medicine from January 2018 to January 2021 were selected. According to the surgical treatment plan, they were divided into two groups. 63 cases underwent laparoscopic surgery as the observation group, and 40 cases underwent open surgery as the control group. The perioperative related indexes of the two groups were compared, and the stress indexes and inflammatory indexes before and after treatment (24 hours after surgery) were counted. The postoperative complications and the recurrence rate of 10 months of follow-up were evaluated. Results The operation time, postoperative exhaust, postoperative first ambulation, hospitalization time, length of surgical incision in the observation group were shorter than those in the control group, and the intraoperative blood loss was less than that in the control group, and the differences were statistically significant (P < 0.05). After treatment, the levels of stress indexes and inflammatory indexes in the two groups were higher than those before treatment, but the stress indexes and inflammatory indexes in the observation group were lower than those in the control group, and the differences were statistically significant (P < 0.05). The postoperative complication rate of the observation group was lower than that of the control group, and the difference was statistically significant (P < 0.05). There was no significant difference in the recurrence rate between the two groups (P > 0.05). Conclusion Laparoscopic surgery in the treatment of adult inguinal hernia, the operation time, postoperative exhaust, the first time to get out of bed after surgery, hospital stay and length of surgical incision are shorter, the stress index and inflammatory index levels are lower than open surgery, which can effectively reduce the incidence of complications.