聚乙二醇结合生物反馈治疗在慢性功能性 便秘伴焦虑抑郁患者中的应用

Application of Polyethylene Glycol Combined with Biofeedback Therapy in Patients with Chronic Functional Constipation Complicated by Anxiety and Depression

摘要:

〔摘 要〕 目的：分析在慢性功能性便秘伴焦虑抑郁患者中应用聚乙二醇结合生物反馈治疗的效果。方法：抽取 2019 年 5 月至 2022 年 5 月期间于东南大学附属中大医院诊治的 140 例慢性功能性便秘伴焦虑抑郁患者，通过随机数 字表法分入观察组与对照组，各 70 例。对照组接受药物治疗，观察组患者在对照组治疗基础上予以生物反馈治疗， 比较两组患者治疗前及治疗后第 7、14、20 天的便秘症状评分、焦虑自评量表评分、生命质量评分（生理功能、躯体 疼痛、社会功能、精神健康、活力）、不良反应发生率（腹痛、大便干结、便血）。结果：观察组患者的便秘症状评 分、焦虑自评量表评分均低于对照组，生命质量评分高于对照组，差异具有统计学意义（P ＜ 0.05）；观察组患者的 不良反应发生率低于对照组，但两组比较差异无统计学意义（P ＞ 0.05）。结论：在慢性功能性便秘伴焦虑抑郁患者 中实施聚乙二醇结合生物反馈治疗，能改善患者的症状，缓解其焦虑水平。

Abstract:

〔Abstract〕 Objective To analyze the effect of polyethylene glycol combined biofeedback therapy in patients with chronic functional constipation and anxiety. Methods A total of 140 patients with chronic functional constipation accompanied by anxiety and depression diagnosed and treated in Zhongda Hospital Affiliated to Southeast University from May 2019 to May 2022 were selected and divided into an observation group and a control group by double-blind method, with 70 patients in each group. The control group received drug therapy, and the observation group was given biofeedback therapy on the basis of the treatment of the control group. The constipation symptom score, self-rating anxiety scale score, quality of life score (physiological function, body pain, social function, mental health, vitality) and the incidence of adverse reactions (abdominal pain, dry stool, hematochezia) were compared between the two groups on the 7th, 14th and 20th days before and after treatment. Results The scores of constipation symptom and self-rating anxiety scale score in the observation group were lower than those in the control group, and the scores of quality of life were higher than those in the control group, the differences were statistically significant (P < 0.05). The incidence of adverse reactions in the observation group was lower than that in the control group, but there was no statistical significance between the two groups (P > 0.05). Conclusion The application of polyethylene glycol combined with biofeedback therapy in patients with chronic functional constipation and anxiety can improve the symptoms of patients and relieve their anxiety level.