3D 打印个体化膝关节假体在动物实验中的效果评价

Effect Evaluation of 3D Printing Individualized Knee Prosthesis in Animal Experiments

摘要:

〔摘 要〕 目的：探究 3D 打印个体化膝关节假体在动物实验中的效果。方法：选取广东河源紫金蓝塘土猪 10 只 作为实验猪，进行膝关节计算机断层扫描（CT）影像采集，将所获得的影像数据导入 Mimics 17.0 软件中，并应用该 软件对断面影像进行修补和擦除，设计出个体化的膝关节假体。对实验猪实行左侧全膝关节表面置换术（TKA），植 入 3D 打印膝关节假体，观察术后实验猪的膝关节伸直、屈曲度，评估左后肢痛觉及肌力，进行影像学检查，观察关 节间隙、假体松动、伤口、假体感染情况。结果：手术实行顺利，术后 3 个月观察发现实验猪左后肢痛觉、肌力及活 动良好。膝关节正侧位 X 线片及 CT 检查结果提示关节假体位置、下肢长度、力线、关节间隙良好，未见明显松动及 感染。结论：3D 打印个体化膝关节假体在 TKA 中的动物实验应用效果良好，具有可行性。

关键词:膝关节骨性关节炎;3D 打印;个体化膝关节假体;全膝关节表面置换术;动物实验

Abstract:

〔Abstract〕 Objective To explore the effect evaluation of 3D printing individualized knee joint prosthesis in animal experiments. Methods A total of 10 Zijin Lantang pigs from Guangdong Heyuan were selected as experimental pigs for computed tomography (CT) image acquisition of knee joint. The obtmined image date were imported into Mimics 17.0 software, and the software was used to repair and erase the sectional image, and personalized knee joint prosthesis was designed. Left total knee arthroplasty (TKA) was performed on experimental pigs, and 3D printing knee prostheses were implanted. The knee extension and flexion of experimental pigs were observed, the pain and muscle strength of the left hindlimb were evaluated, and imaging examination was performed to observe the joint space, prosthesis loosening, wound and prosthesis infection. Results The operation was carried out smoothly, and in 3 months after the operation, the left hind limb pain, muscle strength and activity were good. Anteroposternal and lateral radiographs and CT examination results of the knee joint, anatomical observation of the knee prosthesis complex, indicating that the position of the joint prosthesis, lower limb length, line of force, joint space is good, no obvious loosening and infection. Conclusion The application of 3D printing individual knee prosthesis in animal experiment of TKA is good and feasible.

Key words:Knee joint prosthesis; 3D printing; Personalized knee prosthesis; Total knee surface replacement; Animal experiment