Abstract:〔Abstract〕 Objective To observe the application effect of laparoscopy combined with colonoscopy in the removal of large basal colon polyps in children. Methods A total of 46 children with large basal colic polyps who received surgical treatment in Henan Children's Hospital from June 2018 to June 2022 were selected and divided into a simple group and a combined group according to random number table method, with 23 cases in each group. The simple group was treated with simple laparoscopic polypectomy, and the combined group was treated with laparoscopic polypectomy combined with colonoscopy. The clinical indicators, the changes of serum inflammatory factors and related markers before and after surgery, and the improvement of symptoms were compared between the two groups. Results The operation time, intraoperative blood loss, gastrointestinal function recovery time and total hospital stay in the combination group were all less than those in the simple group, and the differences were statistically significant (P < 0.05). The levels of serum inflammatory factors and related markers in the combination group were lower than those in the simple group after surgery, and the differences were statistically significant (P < 0.05). There was no significant difference in symptom scores between the two groups before and after operation (P > 0.05). Conclusion The application of laparoscopy combined with colonoscopy in the removal of large basal colon polyps in children can remove polyps more thoroughly and reduce the degree of postoperative inflammation in children.