Abstract:〔Abstract〕 Objective To investigate the effect of ultrasound-guided lumbosacral sacral plexus block combined with general anesthesia in patients with hip replacement. Methods A total of 108 patients with hip replacement admitted to Zhengzhou Central Hospital Affiliated to Zhengzhou University from March 2019 to April 2021 were selected and divided into a control group and an observation group according to random number table method, with 54 cases in each group. The control group was given general anesthesia, and the observation group was given general anesthesia combined with ultrasound-guided lumbosacral sacral plexus block. Hemodynamic indexes, cognitive function scores, anesthesia effects and complications were compared between the two groups. Results 15 min after anesthesia (T1), 30 min after anesthesia (T2) and before leaving the operating room (T3), the diastolic blood pressure (DBP), systolic blood pressure (SBP) and heart rate (HR) in the observation group were lower than those in the control group, and the differences were statistically significant (P < 0.05). The total incidence of postoperative delirium in the observation group was lower than that in the control group, and the difference was statistically significant (P < 0.05). The duration of motor block, onset time of anesthesia and postoperative extubation time in observation group were shorter than those in control group, and the differences were statistically significant (P < 0.05). There was no significant difference in the occurrence of complications between the two groups (P > 0.05). Conclusion Ultrasound-guided lumbosacral sacral plexus block combined with general anesthesia is effective and safe for patients with hip replacement.