磷酸铝凝胶联合兰索拉唑治疗胃溃疡临床疗效

Clinical Effect of Aluminum Phosphate Gel Combined with Lansoprazole in the Treatment of Gastric Ulcer

摘要:

〔摘 要〕 目的：探究磷酸铝凝胶联合兰索拉唑对胃溃疡患者的治疗效果及胃功能、血清胃泌素（GAS）、基质 金属蛋白酶 –9（MMP–9）的影响。 方法：选取 2020 年 1 月至 2022 年 4 月在焦作市人民医院接受治疗的胃溃疡患者 86 例，采用随机数表法分为观察组和对照组，各 43 例。对照组患者采用兰索拉唑治疗，观察组患者在对照组基础上 联合磷酸铝凝胶治疗，比较两组患者治疗疗效、血清指标以及不良反应发生情况。 结果：观察组患者总有效率高于对 照组，差异具有统计学意义（P ＜ 0.05）；治疗后，两组患者血清胃蛋白酶原 Ⅰ（PGⅠ）、胃蛋白酶原 Ⅱ（PGⅡ）水平 均下降，且观察组患者血清 PGⅠ、PGⅡ 水平均低于对照组，差异具有统计学意义（P ＜ 0.05）；治疗后，两组患者血 清 GAS、MMP–9 水平均下降，且观察组患者血清 GAS、MMP–9 水平均低于对照组，差异具有统计学意义（P ＜ 0.05）。 结论：磷酸铝凝胶联合兰索拉唑可提高胃溃疡治疗效果，改善患者的胃功能，且不会增加不良反应发生风险。

Abstract:

〔Abstract〕 Objective To explore the therapeutic effect of aluminum phosphate gel combined with Lansoprazole on gastric ulcer patients and the effects of gastric function, serum gastrin (GAS) and matrix metalloproteinase-9 (MMP-9). Methods A total of 86 patients with gastric ulcer who received treatment in Jiaozuo People's Hospital from January 2020 to April 2022 were selected and divided into an observation group and a control group by random number table method, with 43 patients in the two groups. The control group was treated with lansoprazole, and the observation group was treated with aluminum phosphate gel on the basis of the control group. The therapeutic efficacy, serum indexes and occurrence of adverse reactions were compared between the two groups. Results The total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P < 0.05). After treatment, the serum PGⅠ and PGⅡ levels in the two groups were decreased, and the serum PGⅠ and PGⅡ levels in the observation group were lower than those in the control group, the differences were statistically significant (P < 0.05); After treatment, the serum GAS and MMP-9 levels in the two groups were decreased, and the serum GAS and MMP-9 levels in the observation group were lower than those in the control group, the differences were statistically significant (P < 0.05). Conclusion Aluminum phosphate gel combined with lansoprazole can improve the curative effect and gastric function of patients with gastric ulcer without increasing the risk of adverse reactions.