Abstract:〔Abstract〕 Objective To explore the correlation between psychological resilience and comprehensive pulmonary rehabilitation in patients with pneumoconiosis. Methods A total of 140 patients with pneumoconiosis admitted to Shenzhen Prevention and Treatment Center for Occupational Disease from November 2020 to October 2022 were selected as the study subjects. The patient's psychological resilience, quality of life, dyspnea symptoms were evaluated, and the pulmonary function indicators such as orced expiratory volume in the first second (FEV1), maximum ventilatory capacity (MVV), 6-min walking distance were collected. The correlation between psychological resilience and lung function indicators, quality of life was analyzed. Results The score of Connor–Davidson resilience scale (CD–RISC) of the 140 patients with pneumoconiosis was 38 to 75 points, with an average score of (57.18 ± 7.91) points. There were statistically significant differences in the pulmonary function indicators, St .George's respiratory questionnaire (SGRQ) score and Borg scale score of patients with different levels of psychoelastic pneumoconiosis (P < 0.05). The results of correlation analysis showed that the score of CD–RISC in patients with pneumoconiosis was positively correlated with the pulmonary function indicators, 6-min walking distance and SGRQ score (r > 0, P < 0.05), and it was negatively correlated with Borg scale score (r < 0, P < 0.05). Conclusion The psychological elasticity of patients with pneumoconiosis has a high correlation with pulmonary function indexes and quality of life.