CO2 激光联合重组干扰素治疗下生殖道病变临床研究

Clinical Study of CO2 Laser Combined with Recombinant Interferon in the Treatment of Lower Fenital Tract Lesions

摘要:

〔摘 要〕 目的：探究人乳头状瘤病毒（HPV）感染并阴道上皮内瘤变（VAIN）患者采用干扰素配合 CO_{2 激光治 疗的应用效果。 方法：选取常德市第一人民医院 2017 年 7 月至 2019 年 7 月收治的 194 例 HPV 感染并 VAIN 患者， 依据随机数字表法分组为 A 组（64 例，采用 CO2 激光治疗），B 组（64 例，采用 CO2 激光配合保妇康栓治疗）， C 组（66 例，采用 CO2 激光配合干扰素治疗），比较各组患者的疗效。 结果：治疗后 C 组患者的阴道出血量、阴道 排液量低于 A 组、B 组，且阴道出血时间、阴道排液时间少于 A 组、B 组，差异具有统计学意义（P ＜ 0.05）。治 疗后 C 组患者不同时间段的病变逆转率均高于 A 组、B 组，差异具有统计学意义（P ＜ 0.05）。治疗后 2 年各组患 者恶化率比较，差异无统计学意义（P ＞ 0.05）。C 组患者的不同时段病变复发率均低于 A 组、B 组，且不同时段 HPV 转阴率均高于 A 组、B 组，差异具有统计学意义（P ＜ 0.05）。 结论：干扰素配合 CO2 激光治疗可显著减轻本 研究患者术后阴道出血量，且治疗后不易复发。}

Abstract:

〔Abstract〕 Objective To investigate the effect of interferon combined with CO_{2 laser in the treatment of human papilloma virus (HPV) infection and vaginal intraepithelial neoplasa (VAIN). Methods A total of 194 patients with HPV infection and VAIN treated in the First People's Hospital of Changde from July 2017 to July 2019 were selected and divided into group A (64 cases, treated with CO2 laser), group B (64 cases, treated with CO2 laser combined with Baofukang Shuan), and group C (66 cases, treated with CO2 laser combined with interferon) according to random number table method, the efficacy of each group was compared. Results After treatment, the amount of vaginal bleeding and vaginal drainage in group C was lower than that in group A and group B, and the time of vaginal bleeding and vaginal drainage was lower than that in group A and group B, the differences were statistically significant (P < 0.05). After treatment, the reversal rate of lesions in group C was higher than that in group A and group B at different time periods, and the differences were statistically significant (P < 0.05). There was no significant difference in the rate of deterioration 2 years after treatment among all groups (P > 0.05). The recurrence rate of lesions in group C was lower than that in group A and Group B at different periods, and the HPV negative conversion rate was higher than that in group A and group B at different periods, the differences were statistically significant (P < 0.05). Conclusion Interferon combined with CO2 laser therapy can significantly reduce postoperative vaginal bleeding in the patients in this study, and it is not easy to relapse after treatment.}