Abstract:〔Abstract〕 Objective To observe the effect of elliptical machine in patients with unstable angina pectoris (UAP) after percutaneous coronary intervention (PCI). Methods A total of 98 UAP patients receiving PCI in the Second Affiliated Hospital of Zhengzhou University from January 2020 to March 2022 were selected and divided into a control group and an observation group according to random number table method, with 49 cases in each group. The control group was treated with conventional PCI postoperative treatment, and the observation group was treated with elliptical machine at the same time. After 6 months of treatment, cardiac function indexes, serum oxidation response indexes and disease severity were compared between the two groups. Results After treatment, New York Heart Association (NYHA) score of the observation group was lower than that of the control group, left ventricular ejection fraction (LVEF) and 6-min walking distance (6MWT) were higher than those of the control group, the differences were statistically significant (P < 0.05). After treatment, the levels of endothelin (ET) and malondialdehyde (MDA) in the observation group were lower than those in the control group, while the levels of superoxide dismutase (SOD) and nitric oxide (NO) were higher than those in the control group, the differences were statistically significant (P < 0.05). After treatment, the scores of Seattle angina questionnaiire (SAQ) in the observation group were higher than those in the control group, and the differences were statistically significant (P < 0.05). The incidence of muscle soreness and knee discomfort in the observation group was lower than that of the control group, and the differences were statistically significant (P < 0.05). Conclusion The application of the elliptical machine in the treatment of UAP patients after PCI can further improve the cardiac function of patients, adjust the oxidation reaction index of patients, reduce the prognosis of angina pectoris, and reduce the incidence of adverse reactions.