Abstract:〔Abstract〕 Objective To investigate the clinical effect of Yixinshu capsule in the treatment of angina pectoris patients with coronary heart disease. Methods 52 patients with angina pectoris of coronary heart disease admitted to the Second Affiliated Hospital of Hubei University of Science and Technology from May 2021 to May 2022 were selected and divided into a control group and an observation group by random number table method, with 26 cases in each group.The control group was given conventional treatment, and the observation group was combined with Yixinshu capsule on the basis of the control group. The clinical efficacy and hemorheology indexes of the two groups were compared. Results The total effective rate of the observation group was 96.15 %, higher than 69.23 % of the control group, the difference was statistically significant (P < 0.05). Fibrinogen, whole blood specific viscosity and erythrocyte sedimentation rate in the observation group were lower than those of the control group, while hematocrit was higher than that of the control group, the differences were statistically significant (P < 0.05). Conclusion Yixinshu capsule can improve clinical efficacy and hemorheology index in patients with coronary heart disease and angina pectoris.