妊娠合并甲状腺功能减退症的早期治疗对妊娠结局的影响

Effect of Early Treatment of Pregnancy Complicated with Hypothyroidism on Pregnancy Outcome

摘要:

〔摘 要〕 目的：探讨早期治疗对妊娠合并甲状腺功能减退症的效果及对妊娠结局的影响。 方法：选取 2019 年 6 月至 2021 年 6 月于周口市妇幼保健院诊治的 70 例妊娠早期并发甲状腺功能减退患者，以实施治疗时期不同分为对 照组和观察组，各 35 例。对照组在妊娠中期接受甲状腺功能治疗，观察组则在妊娠早期接受甲状腺功能治疗，比较 两组患者疗效、焦虑自评量表（SAS）评分、妊娠并发症发生率及妊娠结局。 结果：观察组患者治疗后血清促甲状腺 激素（TSH）水平、SAS 评分均低于对照组，差异具有统计学意义（P ＜ 0.05）；观察组患者妊娠合并症发生率低于 对照组，差异具有统计学意义（P ＜ 0.05）；观察组患者早产率、新生儿窒息率均低于对照组，差异具有统计学意义 （P ＜ 0.05）。 结论：在妊娠早期对妊娠合并甲状腺功能减退患者实施对症治疗，可有效改善症状，促进胎儿健康发 育，降低患者焦虑情绪与妊娠并发症发生风险。

Abstract:

〔Abstract〕 Objective To investigate the effect of early treatment on pregnancy complicated with hypothyroidism and its influence on pregnancy outcome. Methods A total of 70 patients with hypothyroidism during early pregnancy diagnosed and treated in Zhoukou Maternal and Child Health Hospital from June 2019 to June 2021 were selected and divided into a control group and an observation group according to different treatment periods, with 35 cases in each group. The control group received thyroid function therapy in the second trimester, and the observation group received thyroid function therapy in the first trimester. The efficacy, self-rating anxiety scale (SAS) score, incidence of pregnancy complications and pregnancy outcome were compared between the two groups. Results The level of serum thyroid stimulating hormone (TSH) and SAS score in the observation group were lower than those in the control group after treatment, and the differences were statistically significant (P < 0.05). The incidence of pregnancy complications in observation group was lower than the control group, and the difference was statistically significant (P < 0.05). The preterm birth rate and neonatal asphyxia rate in the observation group were lower than those in the control group, and the difference was statistically significant (P < 0.05). Conclusion Symptomatic treatment for pregnant patients with hypothyroidism in early pregnancy can effectively improve symptoms, promote healthy fetal development, and reduce the risk of anxiety and pregnancy complications.