补肾养经汤治疗 PCOS 患者的临床研究

Study on the Clinical Effect of Bushen Yangjing Decoction on Patients with PCOS

摘要:

〔摘 要〕 目的：探讨补肾养经汤对多囊卵巢综合征（PCOS）患者卵巢功能及血清内脏脂肪素及半乳糖凝集素 –3 的影响。 方法：选取平顶山市中医医院 2020 年 12 月至 2021 年 12 月期间收治的 78 例 PCOS 患者，随机分为对照组 与观察组，各 39 例。对照组患者口服炔雌醇环丙孕酮片治疗，观察组患者口服炔雌醇环丙孕酮片联合补肾养经汤治疗， 两组患者均连续治疗 3 个月经周期，比较两组患者的临床疗效、中医证候积分、卵泡体积及直径 2 ~ 8 mm 的卵泡数、 血清激素水平、血清内脏脂肪素及半乳糖凝集素 –3 水平以及不良反应发生情况。 结果：观察组患者治疗总有效率为 94.87 %，高于对照组的 79.49 %，差异具有统计学意义（P ＜ 0.05）。观察组患者中医证候积分总改善率为 76.92 %， 高于对照组的 48.72 %，差异具有统计学意义（P ＜ 0.05）。治疗后两组患者的卵泡体积及直径 2 ~ 8 mm 的卵泡 数均低于治疗前，且治疗后观察组患者的卵泡体积及直径 2 ~ 8 mm 的卵泡数均低于对照组，差异具有统计学意义 （P ＜ 0.05）。治疗后两组患者的雌二醇（E2）、睾酮（T）、黄体生成素（LH）水平均低于治疗前，且治疗后观察 组患者的 E2、T、LH 水平均低于对照组，差异具有统计学意义（P ＜ 0.05）。治疗后两组患者的 FSH 比较，差异无 统计学意义（P ＞ 0.05）。治疗后两组患者的内脏脂肪素及半乳糖凝集素 –3 水平均低于治疗前，且治疗后观察组患者 的内脏脂肪素及半乳糖凝集素 –3 水平均低于对照组，差异具有统计学意义（P ＜ 0.05）。治疗后观察组患者出现胃肠 道反应 4 例；对照组患者出现胃肠道反应 3 例。观察组患者不良反应发生率为 10.26 %（4/39），较对照组的 7.69 % （3/39）略高，但差异无统计学意义（P ＞ 0.05）。 结论：补肾养经汤对 PCOS 的疗效明显，可改善患者的临床症状， 改善卵巢储备功能，降低血清内脏脂肪素及半乳糖凝集素 –3 水平，且安全性良好。

Abstract:

〔Abstract〕 Objective To study the therapeutic effect of naloxone injection on patients with acute alcoholism. Methods A total of 80 patients with acute alcoholism admitted to Henan Electric Power Hospital from January 2020 to December 2022 were selected as research objects, and were divided into a control group and an observation group by random number table method, with 40 cases in each group. The control group received conventional symptomatic treatment, and the observation group received naloxone injection based on the control group. The therapeutic effects of the two groups were compared. Results After treatment, the arterial partial pressure of oxygen (PaO2), arterial oxygen saturation (SaO2), the levels of superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) in the observation group were higher than those of the control group, while the arterial partial pressure of carbon dioxide (PaCO2) and the level of malondialdehyde (MDA) were lower than those of the control group. The differences were statistically significant (P < 0.05). Symptom disappearance time, consciousness recovery time and hospital stay time in the observation group were shorter than those in the control group, Glasgow coma scale (GCS) score and the total effective rate were higher than those in the control group, acute physiology and chronic health status Ⅱ (Apache-ⅱ) score was lower than that in the control group, the differences were statistically significant (P < 0.05). Conclusion The application of naloxone injection in the treatment of acute alcoholism can improve the blood gas analysis index, reduce the stress response, the efficacy is significant and safe, and can shorten the recovery time of consciousness.