Abstract:〔Abstract〕 Objective To investigate the effect of coronary artery bypass transplantation concurrent with heart valve replacement in the treatment of coronary heart disease with heart valve disease. Methods 100 patients with coronary heart disease and valvular heart disease admitted to Nanyang Central Hospital from January 2021 to December 2021 were randomly divided into a control group and an observation group, with 50 patients in each group. The control group was treated with coronary artery bypass transplantation and heart valve replacement surgery not the same time, while the observation group was treated with coronary artery bypass transplantation and heart valve replacement surgery at the same time. Results The surgical treatment efficiency of the observation group was higher than that of the control group, and the difference was statistically significant (P < 0.05); The observation group had shorter postoperative ventilator application time, intensive care unit (ICU) stay time, and hospitalization time compared to the control group, with statistically significant differences (P < 0.05); Three months after operation, the left ventricular ejection fraction (LVEF) in the observation group was higher than that of the control group, and the left ventricular end diastolic diameter (LVEDD) was lower than that of the control group, with a statistically significant difference (P < 0.05); Three months after surgery, the duration of ischemia in the observation group was shorter than that of the control group, and the number of ischemic occurrences was lower than that of the control group, with a statistically significant difference (P < 0.05); The postoperative incidence of complications in the observation group was lower than that of the control group, and the difference was statistically significant (P < 0.05). Conclusion Coronary artery bypass transplantation concurrent with heart valve replacement can reduce the risk of operation, improve the therapeutic effect, promote the postoperative recovery of patients with coronary heart disease and valvular heart disease, improve cardiac function, and reduce ischemia and postoperative complications.