美托洛尔联合胺碘酮对急性心肌梗死 并发心律失常患者的疗效

Efficacy of Metoprolol Combined with Amiodarone in Patients with Acute Myocardial Infarction Complicated with Arrhythmia

摘要:

〔摘 要〕 目的：分析美托洛尔联合胺碘酮对急性心肌梗死并发心律失常患者氧化应激、炎症反应的影响。 方法：选 取南阳市中心医院 2022 年 2 月至 2022 年 11 月收治的 76 例急性心肌梗死并发心律失常患者，随机分为对照组和观察组， 各 38 例。对照组采用美托洛尔治疗，观察组采用美托洛尔联合胺碘酮治疗。比较两组患者炎症因子水平与氧化应激指标、 心功能、不良反应发生情况。 结果：治疗后，观察组患者左心室舒张末期容积（LVEDV）、左心室收缩末期容积（LVESV）、 血清白细胞介素 –6（IL–6）、肿瘤坏死因子 –α（TNF–α）、C 反应蛋白（CRP）、超氧化物歧化酶（SOD）、丙二醛（MDA）、 脂质过氧化物（LPO）水平低于对照组，左心室射血分数（LVEF）高于对照组，差异具有统计学意义（P ＜ 0.05）。两组 患者不良反应发生率比较，差异无统计学意义（P ＞ 0.05）。 结论：美托洛尔联合胺碘酮可有效治疗急性心肌梗死并发心 律失常，可改善患者心功能、缓解氧化应激反应，降低炎症因子水平，且安全性较高。

Abstract:

〔Abstract〕 Objective To analyze the effects of metoprolol combined with amiodarone on oxidative stress and inflammation in patients with acute myocardial infarction complicated with arrhythmia. Methods A total of 76 patients with acute myocardial infarction complicated with arrhythmia admitted to Nanyang Central Hospital from February 2022 to November 2022 were randomly divided into a control group and an observation group, with 38 patients in each group. The control group was treated with metoprolol, and the observation group was treated with metoprolol combined with amiodarone. The levels of inflammatory factors, oxidative stress indexes, cardiac function and adverse reactions were compared between the two groups. Results After treatment, The left ventricular end-diastolic volume (LVEDV), left ventricular end-systolic volume (LVESV), the levels of serum interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), C-reactive protein (CRP), superoxide dismutase (SOD), malondialdehyde (MDA) and lipid peroxidase (LPO) in the observation group were lower than those in the control group, the left ventricular ejection fraction (LVEF) in the observation group was higher than that in the control group, and the differences were statistically significant (P < 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P > 0.05). Conclusion Metoprolol combined with amiodarone can effectively treat arrhythmia in patients with acute myocardial infarction, improve cardiac function, relieve oxidative stress and reduce the level of inflammatory factors, with high safety.