阿托伐他汀联合温胆汤治疗高脂血症的临床疗效

Clinical Effect of Atorvastatin Combined with Wendan Decoction on Patients with Hyperlipidemia

摘要:

〔摘 要〕 目的：研究阿托伐他汀联合温胆汤加减治疗高脂血症的临床疗效。 方法：采用随机数字表法将 2019 年 5 月至 2021 年 5 月在厦门市湖里区金山街道社区卫生服务中心治疗的高脂血症患者 52 例分为对照组与观察组，各 26 例。 对照组患者采用口服阿托伐他汀钙片治疗，观察组患者在对照组基础上采用温胆汤加减治疗。比较两组患者临床疗效、 中医证候积分、血脂水平［总胆固醇（TC）、低密度脂蛋白胆固醇（LDL–C）、三酰甘油（TG）、高密度脂蛋白胆固醇 （HDL–C）］。 结果：观察组患者治疗总有效率为 92.31 %，高于对照组的 69.23 %，差异具有统计学意义（P ＜ 0.05）； 治疗后观察组患者各项中医证候积分均低于对照组，差异具有统计学意义（P ＜ 0.05）；治疗后观察组患者 HDL–C 水平高于 对照组，LDL–C、TG、TC 水平均低于对照组，差异具有统计学意义（P ＜ 0.05）。 结论：阿托伐他汀联合温胆汤加减治 疗高脂血症效果显著，可改善中医证候，降低血脂，促进病情归转。

Abstract:

〔Abstract〕 Objective To study the clinical effect of atorvastatin combined with Wendan decoction in the treatment of hyperlipidemia. Methods Fifty-two patients with hyperlipidemia admitted to the Community Health Service Center of Jinshan Street in Huli district, Xiamen City from May 2019 to May 2021 were divided into a control group and an observation group with 26 cases in each group by random number table method.The Control group was treated with oral atorvastatin calcium tablets, the observation group was treated with Wendan decoction on the basis of the control group.The clinical efficacy, traditional Chinese medicine (TCM) syndrome scores and blood lipid levels of total cholesterol (TC), low density lipoprotein chesterol (LDL-C), triacylglycerol (TG) and high density lipoprotein cholesteroll (HDL-C) of the two groups were compared. Results The total effective rate of the observation group was 92.31 %, higher than 69.23 % of the control group, the difference was statistically significant (P < 0.05). After treatment, the scores of TCM syndrome in the observation group were lower than those in the control group, and the differences were statistically significant (P < 0.05). After treatment, the HDL-C level in the observation group was higher than that in the control group, and the levels of LDL-C, TG and TC were lower than those in the control group, with statistical significances (P < 0.05). Conclusion Atorvastatin combined with Wendan decoction is effective in the treatment of hyperlipidemia, which can improve TCM syndromes, reduce blood lipids and promote the transformation of the disease.