80 份泌尿生殖道标本解脲脲原体和人型 支原体对常用抗菌药物敏感性分析

Sensitivity Analysis of Ureaplasma Urealyticum and Mycoplasma Hominis to Commonly Used Antimicrobial Agents in 80 Urogenital Specimens

摘要:

〔摘 要〕 目的：分析泌尿生殖道标本解脲脲原体和人型支原体对常用抗菌药物的敏感性，旨在为抗菌药物使用方案 拟定提供参考。 方法：选取 2021 年 6 月至 2023 年 2 月期间平顶山市妇幼保健院采集的 80 份泌尿生殖道标本，借助支原 体培养和药物敏感试验试剂盒给予支原体检测和药物敏感检测。 结果：80 份泌尿生殖道标本中单独检出解脲脲原体 74 份 （92.50 %），同时检出解脲脲原体、人型支原体 4 份（5.00 %），单独检出人型支原体 1 份（1.25 %）。单独检出解脲脲 原体对于四环素、多西环素、米诺环素、克拉霉素及交沙霉素具有较高敏感性；同时检出解脲脲原体、人型支原体对于四 环素、多西环素、米诺环素、克拉霉素及交沙霉素也具有较高敏感性，但敏感性不及单独解脲脲原体；单独检出人型支原 体对四环素类、大环内酯类具有较高敏感性。解脲脲原体、人型支原体对于喹诺酮类抗菌药物均存在较高耐药性。 结论：泌尿生殖道中属解脲脲原体最为常见，其对四环素类及部分大环内酯类抗菌药物的敏感性较高，而对喹诺酮类抗菌药物的 耐药性较高，故临床上需严格按照培养和药物敏感试验结果来选用相应抗菌药物进行治疗，以最大限度地发挥抗菌作用。

Abstract:

〔Abstract〕 Objective To analyze the sensitivity of ureaplasma urealyticum and mycoplasma hominis in urogenital specimens to commonly used antibacterial drugs, in order to provide reference for the formulation of antibacterial drug use plan. Methods 80 samples of urogenital tract collected in Pingdingshan Maternal and Child Health Hospital from June 2021 to February 2023 were selected for mycoplasma detection and drug sensitivity test with the help of mycoplasma culture and drug sensitivity test kit. Results Out of 80 specimens of the urinary and reproductive tract, 74 (92.50%) of them were detected as Ureaplasma urealyticum, while 4 (5.00%) were detected as Ureaplasma urealyticum and Mycoplasma hominis, and 1 (1.25%) was detected as Mycoplasma hominis.Ureaplasma urealyticum isolated is highly sensitive to tetracycline, doxycycline, minocycline, clarithromycin and josamycin. Ureaplasma urealyticum and mycoplasma hominis were also highly sensitive to tetracycline, doxycycline, minocycline, clarithromycin and josamycin, but the sensitivity was not as good as that of Ureaplasma urealyticum alone. Mycoplasma hominis isolated is highly sensitive to tetracycline and macrolide. Ureaplasma urealyticum and mycoplasma hominis are highly resistant to quinolones. Conclusion Ureaplasma urealyticum is the most common in genitourinary tract, which is highly sensitive to tetracyclines and some macrolides, but highly resistant to quinolones. Therefore, it is necessary to select the corresponding antibiotics strictly according to the results of culture and drug sensitivity test in clinic to maximize the antibacterial effect.