Abstract:〔Abstract〕 Objective To study the effect of Chief Physician Nie Yong’s self-formulated Xiaoying Prescription on thyroid antibodies, the size and number of thyroid nodules in patients with benign thyroid nodules complicated with Hashimoto’s thyroiditis. Methods A total of 92 patients with benign thyroid nodules complicated with Hashimoto’s thyroiditis diagnosed and treated in Zhumadian Traditional Chinese Medicine Hospital from May 2022 to May 2023 were selected as the research subjects and randomly divided into a control group and an observation group, with 46 cases in each group. The patients in the control group were treated with levothyroxine sodium tablets, while the patients in the observation group were treated with self-formulated Xiaoying Prescription on the basis of the control group. After 4 months of treatment, the clinical efficacy, traditional Chinese medicine (TCM) syndrome scores, thyroid antibodies, thyroid nodule size and number, and adverse reactions were observed in both groups. Results The total effective rate of treatment in the observation group was higher than that in the control group; the TCM syndrome score of the observation group was lower than that of the control group after treatment; the serum levels of thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TGAb) in the observation group were lower than those in the control group after treatment; the thyroid isthmus thickness, anteroposterior diameter of the two lobes, the longest diameter of the nodules, and the number of nodules in the observation group were all lower than those in the control group after treatment, with statistically significant differences (P < 0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (P > 0.05). Conclusion Chief Physician Nie Yong’s self-formulated Xiaoying Prescription can effectively reduce the level of thyroid autoantibodies in patients with benign thyroid nodules complicated with Hashimoto’s thyroiditis, inhibit the progression of nodules, alleviate clinical symptoms, and has high safety.