血清 LDH、SFA、TK1 在骨髓增生异常 综合征患者中的水平及临床意义

The Levels and Clinical Significance of Serum LDH, SFA, and TK1 in Patients with Myelodysplastic Syndrome

摘要:

〔摘 要〕 目的：探究骨髓增生异常综合征（MDS）患者血清乳酸脱氢酶（LDH）、叶酸（SFA）、胸苷激酶 1（TK1） 的临床意义。 方法：回顾性选取福州市第一医院 2020 年 3 月至 2023 年 3 月收治的 80 例 MDS 患者作为观察组，另选取同 期来福州市第一医院体检的 80 例健康人群作为对照组，比较观察组和对照组的 LDH、SFA 和 TK1 水平；另根据观察组疾 病严重程度分为低危组 25 例、中危组 26 例和高危组 29 例，比较三组患者血清 LDH、SFA、TK1 水平，并采用 Spearman 相关系数分析 MDS 患者 LDH、SFA、TK1 与疾病严重程度的相关性。 结果：观察组患者血清 LDH、TK1 水平高于对照组， SFA 低于对照组；中危组和高危组的 LDH、TK1 水平高于低危组，SFA 水平低于低危组，且高危组 LDH 和 TK1 水平更高， SFA 水平更低，差异均具有统计学意义（P ＜ 0.05）；经 Spearman 相关分析，MDS 患者疾病严重程度与 SFA 水平呈负 相关（ρ = –0.893，P ＜ 0.001），与 LDH 水平（ρ = 0.952，P ＜ 0.001）、TK1 水平（ρ = 0.926，P ＜ 0.001）呈正相关。 结论：LDH、SFA、TK1 水平与 MDS 的疾病严重程度关系密切，可为临床 MDS 的诊断及病情评估提供参考。

Abstract:

〔Abstract〕 Objective To investigate the clinical significance of serum lactate dehydrogenase (LDH), folate (SFA), and thymidine kinase 1 (TK1) in patients with myelodysplastic syndrome (MDS). Methods 80 MDS patients admitted to Fuzhou First Hospital from March 2020 to March 2023 were retrospectively selected as the observation group, and 80 healthy individuals who underwent physical examinations at Fuzhou First Hospital during the same period were selected as the control group. LDH, SFA, and TK1 levels were compared between the observation group and the control group; In addition, according to the severity of disease in the observation group, the patients were divided into low-risk group (25 cases), medium-risk group (26 cases) and high-risk group (29 cases). The levels of serum LDH, SFA, and TK1 in the three groups will be compared, and the Spearman correlation coefficient will be used to analyze the correlation between LDH, SFA, TK1 and disease severity in MDS patients. Results The levels of serum LDH and TK1 in the observation group were higher than those in the control group, while SFA was lower than that in the control group; The LDH and TK1 levels in the medium and high-risk groups were higher than those in the low-risk group, while the SFA levels were lower than those in the low-risk group. In addition, the LDH and TK1 levels were higher and the SFA levels were lower in the high-risk group, and the differences were statistically significant (P < 0.05); According to Spearman correlation analysis, the severity of MDS patients is negatively correlated with SFA levels (ρ = – 0.893, P < 0.001), at LDH level (ρ = 0.952, P < 0.001), TK1 level (ρ = 0.926, P < 0.001) shows a positive correlation. Conclusion The levels of LDH, SFA, and TK1 are closely related to the severity of MDS, and can provide reference for the diagnosis and evaluation of clinical MDS.