血清生化指标联合检测诊断肝癌的应用价值

Application Value of Serum Biochemical Index Combined Detection in the Diagnosis of Liver Cancer

摘要:

〔摘 要〕 目的：探究血清铁蛋白（SF）、谷氨酰转肽酶（GGT）、腺苷脱氨酶（ADA）、5– 核苷酸酶（5–NT）联合 检测在原发性肝癌（PHC）中的诊断价值。 方法：选取郑州市第二人民医院 2018 年 6 月至 2020 年 10 月收治的 51 例 PHC 患者作为 PHC 组，选取同期收治的 48 例肝硬化患者纳入良性组，比较两组患者的血清 SF、GGT、ADA、5–NT 水平，并 比较两组患者血清 SF、GGT、ADA、5–NT 及联合检测的阳性检出率。 结果：PHC 组患者的血清 SF、GGT、ADA、5–NT 水平均高于良性组，差异具有统计学意义（P ＜ 0.05）；PHC 组患者血清 SF、GGT、ADA、5–NT 单项及联合检测阳性检 出率均高于良性组，差异具有统计学意义（P ＜ 0.05）。 结论：血清 SF、GGT、ADA 和 5–NT 联合检测在 PHC 的鉴别诊 断中具有较高的临床应用价值，依据各指标水平的变化判断患者病情严重程度，较好弥补单项检测的不足，因此各指标联 合检测可为临床诊断及治疗方案制定提供更可靠的依据。

Abstract:

〔Abstract〕 Objective To investigate the diagnostic value of combined detection of serum ferritin (SF), gamma glutamyl transferase (GGT), adenosine deaminase (ADA) and 5-nucleotidase (5-NT) in primary liver cancer (PHC). Methods 51 cases of patients with PHC who were admitted to the Second People's Hospital of Zhengzhou from June 2018 to October 2020 were selected as the PHC group, and 48 cases of patients with cirrhosis who were admitted during the same period were included in the benign group. The levels of serum SF, GGT, ADA and 5-NT were compared between the two groups, and the positive detection rates of SF, GGT, ADA, 5-NT and combined detection were compared between the two groups. Results The levels of serum SF, GGT, ADA and 5-NT in PHC group were higher than those in benign group, and the differences were statistically significant (P < 0.05). The positive detection rates of serum SF, GGT, ADA, 5-NT and their combined detection in the PHC group were higher than those in the benign group, and the differences were statistically significant (P < 0.05). Conclusion The combined detection of serum SF, GGT, ADA and 5-NT has high clinical application value in the differential diagnosis of PHC. The severity of patients' disease can be judged according to the changes in the level of each indicator, which can better make up for the deficiencies of single detection. Therefore, the combined detection of each indicator can provide a more reliable basis for clinical diagnosis and treatment plan.