Abstract:〔Abstract〕 Objective To evaluate the application effect of digital technology in drug maintenance work at the intravenous drug preparation center. Methods Drug maintenance data from May 1, 2022, to August 31, 2023, were extracted from the information system of the Intravenous Drug Preparation Center of the Second Affiliated Hospital of Xiamen Medical College. The data were compared before (May 1, 2022, to December 31, 2022) and after (January 1, 2023, to August 31, 2023) the digital technology transformation, including the coverage rate of drug maintenance, the completeness of maintenance items, the number of expired drugs, the completion rate of staff, and satisfaction. Results Before the digital technology transformation of drug maintenance, the overall satisfaction of 26 staff members with the maintenance work was (3.43 ± 1.57) points, which increased to (4.31 ± 0.84) points after the transformation, with a statistically significant difference (P < 0.01). After the digital technology transformation of drug maintenance, there were statistically significant differences in the coverage rate of drug maintenance, the completeness of maintenance items, and the on-time completion rate of staff (P < 0.01). Conclusion The application of digital technology in drug maintenance at the intravenous drug preparation center has improved the effect of drug maintenance, including the coverage rate, the completeness of maintenance items, the completion rate of staff, and satisfaction, providing a guarantee for the rational use of drugs.