Abstract:〔Abstract〕 Objective To investigate the influence of adenoidectomy combined with tonsillectomy on sleep quality in children with obstructive sleep apnea hypopnea syndrome (OSAHS). Methods 98 children with OSAHS who were treated in Zhengzhou children's hospital from January 2021 to July 2022 were selected and randomly divided into a control group and an observation group, 49 cases in each group. The control group was treated with simple adenoidectomy, while the observation group was treated with adenoidectomy combined with tonsillectomy. The clinical efficacy after posttreatment, levels changes of apnea-hypopnea index (AHI), obstructive sleep apnea index (OAI) and lowest oxygen saturation (LSaO2), sleep quality and the impact of OSAHS on the quality of life before and after operation were compared between the two groups, the complications within 6 months were counted. Results The clinical treatment efficiency of the observation group after treatment was higher than that of the control group, and the difference was statistically significant (P < 0.05). Compared with preoperative, the levels of AHI and OAI at discharge in both groups decreased, and the AHI and OAI levels in the observation group were lower than those in the control group, the differences were statistically significant (P < 0.05); the LSaO2 levels at discharge in both groups were significantly higher than that before operation, the differences were statistically significant (P < 0.05), but there was no statistically significant difference in LSaO2 levels between the groups (P > 0.05). Compared with preoperative, the scores of Pittsburgh sleep quality index (PSQI), Epworth sleepiness scale (ESS) and children OSAHS specific quality of life questionnaire (OSA-18) at discharge in both groups decreased, and the scores of PSQI, ESS and OSA-18 in the observation group were lower than those of the control group, the differences were statistically significant (P < 0.05). The incidence of complications within 6 months after operation in the observation group was lower than that in the control group, and the difference was statistically significant (P < 0.05). Conclusion The adenoidectomy combined with tonsillectomy can more effectively reduce AHI and OAI in children with OSAHS, improve their sleep and quality of life, and reduce the risk of postoperative tonsil re proliferation and recurrent inflammation, the overall clinical efficacy is better than simple adenoidectomy. It is recommended to remove both adenoids and tonsils simultaneously for children with adenoid and tonsil hypertrophy.